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Properties of substance:

dl-propranolol hydrochloride



skc-file

Group of substances:

organic

Physical appearance:

white crystals

Empirical formula (Hill's system for organic substances):

C16H22ClNO2

Molar/atomic mass: 295.80438

Melting point (°C):

164

CAS №: 318-98-9

Solubility (g/100 g of solvent):

carbon tetrachloride: 0.019 (20°C) [Ref.]
chloroform: sparingly soluble 1.14 (20°C) [Ref.]
diethyl ether: practically insoluble 0.007 (20°C) [Ref.]
ethanol: 8.6 (20°C) [Ref.]
heptane: 0.0044 (20°C) [Ref.]
hexane: 0.0053 (20°C) [Ref.]
water: 9 (20°C) [Ref.]

LD50 (mg/kg):

449 (, oral)
612 (, oral)
331 (, oral)
191 (, intraperitoneal)
231 (, oral)
138 (, intraperitoneal)

Spectral properties of the substance:

Ultraviolet/visible spectrum (maximum in nm, layer thickness 1 cm, in parentheses - extinction) = 217 (135)
Ultraviolet/visible spectrum (maximum in nm, layer thickness 1 cm, in parentheses - extinction) = 293 (22)

References:

  1. Clarke's isolation and identification of drugs. - 2ed. - London: Pharmaceutical press, 1986. - pp. 936-938
  2. Elks J., Ganellin C.R. Dictionary of Drugs: Chemical Data, Structures and Bibliographies. - Springer, 1990. - pp. 1034
  3. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 1735-1736
  4. Вартанян Р.С. Синтез основных лекарственных средств. - М.: МИА, 2004. - pp. 231-232 [Russian]
  5. Полюдек-Фабини Р., Бейрих Т. Органический анализ. - Л.: Химия, 1981. - pp. 580 [Russian]
  6. Регистр лекарственных средств России: Энциклопедия лекарств. - 8 изд. - М., 2001. - pp. 733 [Russian]
  7. Судебно-медицинская экспертиза. - 1982. - №4. - pp. 44 [Russian]
  8. Токсикологический вестник. - 1993. - №2. - pp. 43 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru