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Properties of substance:
triamcinolone acetonide
skc-file
Group of substances:
organic
Physical appearance:
white crystals
Empirical formula (Hill's system for organic substances):
C
2
4
H
3
1
FO
6
Molar/atomic mass: 434.498
Melting point (°C):
292-294
CAS №: 76-25-5
Solubility (g/100 g of solvent):
acetone
: 9.1 [
Ref.
]
chloroform
: 2.5 [
Ref.
]
ethanol
: 0.67 [
Ref.
]
ethanol abs.
: sparingly soluble [
Ref.
]
ethyl acetate
: sparingly soluble [
Ref.
]
methanol
: sparingly soluble [
Ref.
]
water
: 0.0021 (28°C) [
Ref.
]
water
: 0.00255 (37°C) [
Ref.
]
water
: 0.00336 (50°C) [
Ref.
]
LD
50
(mg/kg):
13.1 (rats, subcutaneous)
5000 (mice, oral)
132 (mice, subcutaneous)
105 (mice, intraperitoneal)
References:
Clarke's Analysis of Drugs and Poisons. - 4 ed. - London, 2011. - pp. 2181
Elks J., Ganellin C.R. Dictionary of Drugs: Chemical Data, Structures and Bibliographies. - Springer, 1990. - pp. 1228
Kleemann A. Pharmaceutical Substances. - 2000. - pp. 2097-2098
Mills T. III, Roberson J.C. Instrumental data for drug analysis. - 2 ed., Vol. 5, 1993. - pp. 404-405
The Merck Index. - 15th ed. - Royal Society of Chemistry, 2013. - pp. 1778-1779
Машковский М.Д. Лекарственные средства. - 15-е изд. - М.: Новая волна, 2007. - pp. 573-574 [Russian]
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© Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru