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Properties of substance:

clonidine hydrochloride



skc-file

Group of substances:

organic

Physical appearance:

white crystals

Empirical formula (Hill's system for organic substances):

C9H10Cl3N3

CAS No: 4205-91-8

Molar/atomic mass: 266.57

Melting point (°C):

314

Decomposition temperature (°C):

316

Solubility (g/100 g of solvent):

chloroform: 0.013 [Ref.]
diethyl ether: practically insoluble [Ref.]
ethanol: 5 [Ref.]
ethanol: 20 (78°C) [Ref.]
ethanol abs.: 2.6 [Ref.]
methanol: 21.84 [Ref.]
water: 7 (20°C) [Ref.]
water: 16.6 (60°C) [Ref.]
water: 50 (100°C) [Ref.]

    LD50 (mg/kg):

    190 (, oral)
    236 (, intraperitoneal)
    126 (, oral)
    21.2 (, intraperitoneal)
    70 (, intraperitoneal)
    192 (, oral)
    60.3 (, oral)
    166 (, intraperitoneal)
    33.8 (, intraperitoneal)
    135 (, oral)
    24.7 (, oral)
    104 (, intraperitoneal)

    References:

    1. Armarego W. L. F. Purification of Laboratory Chemicals. - 7ed. - 2013. - pp. 867
    2. Clarke's Analysis of Drugs and Poisons. - 4 ed. - London, 2011. - pp. 1138-1140
    3. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 523
    4. Lewis R.J. Sax's Dangerous Properties of Industrial Materials. - 12ed., Vol. 1-5. - Wiley, 2012. - pp. 1178
    5. Mills T. III, Roberson J.C. Instrumental data for drug analysis. - 2 ed., vol.1, 1993. - pp. 514-515
    6. Milne G.W.A. Gardner's Commercially Important Chemicals. - Wiley-Interscience, 2005. - pp. 151
    7. Sittig M. Pharmaceutical Manufacturing Encyclopedia. - 2ed. - Westwood, 1988. - pp. 372-373
    8. The Merck Index 11th ed., Merck & Company, 1989. - pp. 374
    9. Вартанян Р.С. Синтез основных лекарственных средств. - М.: МИА, 2004. - pp. 218-219 [Russian]
    10. Токсикологический вестник. - 1995. - №4. - pp. 9-11 [Russian]
    11. Токсикологический вестник. - 1999. - №5. - pp. 35-36 [Russian]
    12. Химическая энциклопедия. - Т. 2. - М.: Советская энциклопедия, 1990. - pp. 410 [Russian]
    13. Яхонтов Л.Н., Глушков Р.Г. Синтетические лекарственные средства. - М.: Медицина, 1983. - pp. 208-211 [Russian]
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      © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru