Selectively couple an aliphatic amine instead of an aromatic

Selectively couple an aliphatic amine instead of an aromatic

Сообщение carterturner » Пт авг 18, 2017 8:31 pm

considering that a molecule of interest has both aliphatic amines and aromatic amines, how would you go about making a carbamate linkage via couplIng the aliphatic amine to a carboxylic acid??? Without reacting the aromatic amine?

I was thinking about edc but that does not give as pure of a product especially when it is in excess. Another option is using methylmorpholine and cdmt but my concern is with the hazards associated with working with the mmp. CDI is another possibility however it cannot be used in aqueous solution which I prefer to have the reaction take place in.



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