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Properties of substance:

1,2-benzisothiazol-3(2H)-one 1,1-dioxide



skc-file

Synonyms:

saccharin

Group of substances:

organic

Physical appearance:

colorless monoclinic crystals

Empirical formula (Hill's system for organic substances):

C7H5NO3S

Molar/atomic mass: 183.19

Melting point (°C):

225

Solubility (g/100 g of solvent):

acetone: 7.69 (0°C) [Ref.]
acetone: 16.8 (50°C) [Ref.]
benzene: soluble [Ref.]
chloroform: difficulty soluble [Ref.]
diethyl ether: difficulty soluble [Ref.]
ethanol: 3.9 (20°C) [Ref.]
ethyl acetate: soluble [Ref.]
trichloroethylene: 0.012 (15°C) [Ref.]
water: 0.43 (25°C) [Ref.]
water: 4 (100°C) [Ref.]
xylene: soluble [Ref.]

Numerical data:

Sweetness potency сompared with a 2% (w/v) aqueous solution of sucrose: 300-350

    Dissociation:

    pKa (1) = 1.3 (20°C, water)

    LD50 (mg/kg):

    17000 (mice, oral)

    References:

    1. Armarego W. L. F. Purification of Laboratory Chemicals. - 7ed. - 2013. - pp. 484
    2. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 1847-1848
    3. Lewis R.J. Sax's Dangerous Properties of Industrial Materials. - 11ed. - Wiley-interscience, 2004. - pp. 374
    4. Mitchell H. Sweeteners and Sugar Alternatives in Food Technology, 2006. - pp. 104-118
    5. Nabors L.O. Alternative Sweeteners. - 3 ed. - Marcel Dekker, 2001. - pp. 147-165
    6. O'Donnell K., Kearsley M. Sweeteners and Sugar Alternatives in Food Technology. - 2 ed. - Wiley-Blackwell, 2012. - pp. 139-151
    7. Seidell A. Solubilities of organic compounds. - 3ed., vol.2. - New York: D. Van Nostrand Company, 1941. - pp. 478
    8. Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 356
    9. Крутошикова А., Угер М. Природные и синтетические сладкие вещества. - М.: Мир, 1988. - pp. 73-80 [Russian]
    10. Справочник химика. - Т. 2. - Л.-М.: Химия, 1964. - pp. 940-941 [Russian]
    11. Химическая энциклопедия. - Т. 4. - М.: Советская энциклопедия, 1995. - pp. 295 [Russian]
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      © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru