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Properties of substance:

sodium salicylate


Physical appearance:

white crystals

Empirical formula (Hill's system):

C7H5NaO3

Structural formula:

HOC6H4COONa

Molar/atomic mass: 160.103

Melting point (°C):

440

Solubility (g/100 g of solvent):

water: 25.09 (-1.5°C)
water: 108 (15°C)
water: 125 (25°C)
water: 145.8 (78.5°C)
water: 179 (114°C)
glycerol: 20 (20°C)
1,4-dioxane: 0.158 (25°C)
diethyl ether: practically insoluble
methanol: 26.28 (15°C)
methanol: 34.73 (67.2°C)
propanol: 1.16 (20°C)
chloroform: practically insoluble
ethanol: 21.4 (15°C)

    LD50 (mg/kg):

    930 (rats, oral)
    560 (mice, intravenous)
    540 (mice, oral)
    562 (dogs, intravenous)

    References:

    1. Clarke's Analysis of Drugs and Poisons. - 4 ed. - London, 2011. - pp. 2040
    2. Jouyban A. Handbook of solubility data for pharmaceutacals. – CRC Press, 2010. - pp. 73
    3. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 1852
    4. Lewis R.J. Sax's Dangerous Properties of Industrial Materials. - 12ed., Vol. 1-5. - Wiley, 2012. - pp. 4040-4041
    5. Lewis R.J. Sax's Dangerous Properties of Industrial Materials. - 12ed., Vol. 1-5. - Wiley, 2012. - pp. 4040-4041
    6. Seidell A. Solubilities of inorganic and metal organic compounds. - 3ed., vol.1. - New York: D. Van Nostrand Company, 1940. - pp. 1173, 1178
    7. The Merck Index 11th ed., Merck & Company, 1989. - pp. 1367-1368
    8. Беликов В.Г. Учебное пособие по фармацевтической химии. - М.: Медицина, 1979. - pp. 169
    9. Краткий справочник химика. - Под ред. Перельмана В.И. - М.-Л.: Химия, 1964. - pp. 188-189
    10. Справочник по растворимости. - Т.1, Кн.1. - М.-Л.: ИАН СССР, 1961. - pp. 142, 676
    11. Халецкий А.М. Фармацевтическая химия. - Л.: Медицина, 1966. - pp. 169
    12. Химический энциклопедический словарь. - Под ред. Кнунянц И.Л. - М.: Советсткая энциклопедия, 1983. - pp. 364
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      © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru