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Properties of substance:

2,5-dihydroxybenzoic acid

Synonyms:

gentisic acid

Group of substances:

organic

Physical appearance:

crystals

Empirical formula (Hill's system for organic substances):

C7H6O4

Structural formula as text:

(HO)2C6H3COOH

CAS No: 490-79-9

Molar/atomic mass: 154.12

Melting point (°C):

205

Decomposition temperature (°C):

205

Solubility (g/100 g of solvent):

benzene: insoluble [Ref.]
carbon disulphide: insoluble [Ref.]
chloroform: sparingly soluble [Ref.]
diethyl ether: very soluble [Ref.]
ethanol: very soluble [Ref.]
water: 0.83 (0°C) [Ref.]
water: 2.2 (25°C) [Ref.]

    Dissociation:

    pKa (1) = 2.97 (25°C, water)
    pKa (2) = 10.5 (25°C, water)

    LD50 (mg/kg):

    4500 (mice, oral)
    374 (mice, intravenous)

    References:

    1. Catalog handbook of fine chemicals Aldrich, 1992-1993. - pp. 461
    2. Dictionary of organic compounds. - Vol. 2, Eccaine - Myrtillin chloride. - London, 1946. - pp. 108
    3. Journal of Physical and Chemical Reference Data. - 2013. - Vol. 42, No. 3. - pp. 033103-262 - 033103-263
    4. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 959-960
    5. Seidell A. Solubilities of organic compounds. - 3ed., vol.2. - New York: D. Van Nostrand Company, 1941. - pp. 531
    6. Stahl P.H., Wermuth C.G. Handbook of Pharmaceutical Salts: Properties, Selection, and Use. - Wiley-VCH, 2002. - pp. 283-284
    7. The Merck Index 11th ed., Merck & Company, 1989. - pp. 688
    8. Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 378
    9. Халецкий А.М. Фармацевтическая химия. - Л.: Медицина, 1966. - pp. 171 [Russian]
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      © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru