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Properties of substance:

salicylic acid


2-hydroxybenzoic acid;

Physical appearance:

colorless crystals

Empirical formula (Hill's system):

C7H6O3

Structural formula:

HOC6H4COOH

Molar/atomic mass: 138.121

Melting point (°C):

159

Destruction point (°C):

200

Solubility (g/100 g of solvent):

1-butanol: 32.2 (24°C)
acetone: 39.6 (23°C)
benzene: 0.46 (11.7°C)
benzene: 0.78 (25°C)
benzene: 4.4 (64.2°C)
water: 0.18 (20°C)
water: 1.76 (75°C)
heptane: 2.13 (92.2°C)
glycerol 86.5%: 0.97 (20°C)
glycerol 98.5%: 1.63 (20°C)
1,4-dioxane: 65.44 (25°C)
diethyl ether: 71.1 (15°C)
castor oil: 14.8 (23°C)
methanol: 40.67 (-3°C)
methanol: 62.48 (21°C)
olive oil: 2.43 (23°C)
p-cymene: 0.974 (25°C)
pentachloroethane: 0.63 (25°C)
propanol: 37.67 (21°C)
carbon disulphide: slightly soluble
carbon tetrachloride: 0.263 (25°C)
trichloroethylene: 0.28 (15°C)
chloroform: 1.57 (30.5°C)
ethanol: 49.6 (15°C)
ethyl acetate: 38 (25°C)

Density:

1.443 (20°C, g/cm3)

Vapour pressure (Torr):

20 (211°C)

Dissociation:

pKa (1) = 3 (25°C, water)
pKa (1) = 6.9 (25°C, dimethylsulphoxide)
pKa (1) = 4.46 (20°C, formamide)
pKa (2) = 13.82 (20°C, water)

LD50 (mg/kg):

891 (rats, oral)
184 (mice, intravenous)
480 (mice, oral)

    References:

    1. Jouyban A. Handbook of solubility data for pharmaceutacals. – CRC Press, 2010. - pp. 72
    2. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 1852-1853
    3. Seidell A. Solubilities of organic compounds. - 3ed., vol.2. - New York: D. Van Nostrand Company, 1941. - pp. 517-528
    4. Stahl P.H., Wermuth C.G. Handbook of Pharmaceutical Salts: Properties, Selection, and Use. - Wiley-VCH, 2002. - pp. 303
    5. Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 373-375
    6. Вредные вещества в промышленности: Справочник для химиков, инженеров и врачей. - 7-е изд., Т.2. - Л.: Химия, 1976. - pp. 136
    7. Глущенко Н.Н., Плетенева Т.В., Попков В.А. Фармацевтическая химия. - М.: Academa, 2004. - pp. 222-229
    8. Рабинович В.А., Хавин З.Я. Краткий химический справочник. - Л.: Химия, 1977. - pp. 223
    9. Справочник по растворимости. - Т.1, Кн.1. - М.-Л.: ИАН СССР, 1961. - pp. 472-473
    10. Справочник по растворимости. - Т.1, Кн.2. - М.-Л.: ИАН СССР, 1962. - pp. 1030, 1142, 1223, 1302, 1485-1488
    11. Справочник химика. - Т.2. - Л.-М.: Химия, 1964. - pp. 938-939
    12. Хёрд Ч.Д. Пиролиз соединений углерода. - Л.-М.: ГОНТИ РКТП СССР, 1938. - pp. 432-433
    13. Химическая энциклопедия. - Т.4. - М.: Советская энциклопедия, 1995. - pp. 288-289
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      © Collected Kiper Ruslan Anatolievich